THE SCIENCE

THE EVOLUTION OF LYMPHATIC RESEARCH

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2003

Collaborative research on the correlation between
lymphatic capillaries and skin
with the Cutaneous Biology Research Center*

*Cutaneous Biology Research Center (CBRC): Established by Harvard Medical University
and Massachusetts General Hospital in 1989 with the support of Shiseido,
CBRC is a comprehensive research center for advanced research and development in the field of dermatology.

2006

Discovered that functional deterioration of lymphatic capillaries
links to
the causes of skin aging

2008

Discovered that lymphatic functions deteriorate
due to UV rays

2014

Discovered that lymphatic capillaries degenerate**
and impurities leak due to
UV rays and aging
Inductive factors which
play a role in collecting
inflammatory factors decrease due to aging

**Degeneration: shrinking of lymphatic capillaries due to damage caused by UV rays.

2017

Developed unique technology to observe
lymphatic capillaries in three dimensions
Discovered lymphatic capillaries are lost partly due to aging

LYMPHATIC CAPILLARIES

Key to Promoting Skin Purification
and Regeneration

Damaged lymphatic capillaries

Strengthened lymphatic capillaries

THE APPROACH: PURIFYING BEAUTY COMPLEX

Prevents the Loss of Lymphatic
Capillaries Due to Aging

MULBERRY WHITE BARK

LAMIUM ALBUM LEAF

CINNAMOMUM CASSIA BARK

EFFICACY DATA ON SKIN'S MOISTURE LEVEL
WITH THE USE OF PURIFYING BEAUTY COMPLEX

THE ROLE OF PURIFICATION IN SKIN'S REGENERATION FUNCTION

Skin that has higher purification and regeneration abilities preserves a larger number of epidermal stem cells.
Therefore, a large number of these cells means a higher ability to generate new epidermal cells.

Skin with deteriorated ability
to purify and regenerate Itself

Skin with higher ability
to purify and regenerate Itself